Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets
Dietary Supplementation with L-Arginine Partially Counteracts Serum Metabonome Induced by Weaning Stress in Piglets
复制标题
DOI：
10.1021/pr200688u
复制
发表时间：
2011-11-01
影响因子：
4.4
通讯作者：
Wang, Yulan
中科院分区：
文献类型：
--
作者：
He, Qinghua;Tang, Huiru;Wang, Yulan
精氨酸在预防早期断奶应激引起的肠道功能障碍和代谢紊乱方面具有重要作用。然而，很少有人知道精氨酸如何减轻早期断奶应激。本研究采用1H-1 NMR光谱结合多变量数据分析的方法，评价断奶应激和日粮精氨酸补充对仔猪血清中代谢物组的影响。将30头21日龄去势雄性仔猪平均分为3组，分别采用母猪饲喂（SF）、断奶时补充L-丙氨酸（ALA）和断奶时补充精氨酸（ARG）3种不同的饲喂方式。我们发现，早期断奶应激导致仔猪增重显著降低（15.6%），补充精氨酸可提高仔猪生长速度5.6%（P
Arginine plays an important role in preventing intestinal dysfunction and metabolic disorders caused by early weaning stress. However, little is known about how arginine mitigates early weaning stress. This study was conducted to evaluate the effects of weaning stress and dietary arginine supplementation on the metabonome in the serum of piglets using H-1 NMR spectroscopy in conjunction with multivariate data analysis. Thirty castrated male piglets aged 21 d were evenly divided into three groups and fed in three different regimes: sow-fed (SF), weaned with L-alanine supplementation (ALA), and weaned with arginine supplementation (ARG). We found that early weaning stress led to a significantly reduced bodyweight gain (15.6%) and that supplementation with arginine can improve growth rates in piglets by 5.6% (P