Rendering protein structures inside cells at the atomic level with Unreal Engine.
Rendering protein structures inside cells at the atomic level with Unreal Engine.
复制标题
使用虚幻引擎在原子级别渲染细胞内的蛋白质结构。
DOI：
10.1101/2023.12.08.570879
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Chen,Muyuan
中科院分区：
文献类型：
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作者：
Chen,Muyuan
虽然低温电子断层扫描（CryoET）的最新发展使识别细胞内的各种大分子并以近原子分辨率确定其结构成为可能，但在原子水平上可视化复杂的细胞环境仍然具有挑战性。细胞可视化的主要障碍之一是在计算上以真实的时间呈现数百万个分子。在这里，使用视频游戏引擎，我们展示了在原子水平上渲染大量生物大分子的能力。为了促进可视化，我们还提供了有助于细胞内交互式导航的工具，以及将使用CryoET识别的蛋白质结构转换为可以使用游戏引擎探索的场景的软件。
While the recent development of cryogenic electron tomography (CryoET) makes it possible to identify various macromolecules inside cells and determine their structure at near-atomic resolution, it remains challenging to visualize the complex cellular environment at the atomic level. One of the main hurdles in cell visualization is to render the millions of molecules in real time computationally. Here, using a video game engine, we demonstrate the capability of rendering massive biological macromolecules at the atomic level within their native environment. To facilitate the visualization, we also provide tools that help the interactive navigation inside the cells, as well as software that converts protein structures identified using CryoET to a scene that can be explored with the game engine.