Micro- and Nanotechnologies for Optical Neural Interfaces.
Micro- and Nanotechnologies for Optical Neural Interfaces.
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DOI：
10.3389/fnins.2016.00070
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发表时间：
2016
影响因子：
4.3
通讯作者：
De Vittorio M
中科院分区：
文献类型：
--
作者：
Pisanello F;Sileo L;De Vittorio M
在过去的十年中，与哺乳动物大脑在体内光学接口的可能性，允许前所未有的神经回路的功能连接的调查。随着新的遗传和分子技术来光学触发和监测神经活动，新一代的光学神经接口正在开发中，这主要归功于自下而上和自上而下的纳米纤维方法的开发。这篇综述强调了纳米技术在光学神经接口中的作用，特别强调了光遗传学控制神经活动的新设备和方法，以及使用光学活性胶体纳米颗粒检测和触发动作电位的非常规方法。
In last decade, the possibility to optically interface with the mammalian brain in vivo has allowed unprecedented investigation of functional connectivity of neural circuitry. Together with new genetic and molecular techniques to optically trigger and monitor neural activity, a new generation of optical neural interfaces is being developed, mainly thanks to the exploitation of both bottom-up and top-down nanofabrication approaches. This review highlights the role of nanotechnologies for optical neural interfaces, with particular emphasis on new devices and methodologies for optogenetic control of neural activity and unconventional methods for detection and triggering of action potentials using optically-active colloidal nanoparticles.