Tissue crosstalk in lung development.
Tissue crosstalk in lung development.
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DOI：
10.1002/jcb.24811
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发表时间：
2014-09
影响因子：
4
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Hines EA;Sun X
肺的发育遵循一个由上皮和间充质组织之间的关键相互作用协调的刻板程序。偏离这一发育程序可导致肺部疾病，包括支气管肺发育不良和肺动脉高压。已经作出了重大努力，以检查这些刻板的发展过程中的组织相互作用的细胞和分子基础。基因工程小鼠模型、肺器官培养和先进的成像技术是扩大我们对驱动肺发育的组织相互作用的理解的一些工具。在上皮和间充质、不同的间充质组织和单个上皮细胞类型之间已经确定了密切的串扰。对于诸如上皮-间充质串扰调节肺特化和分支形态发生的相互作用，关键分子参与者FGF、BMP、WNT和SHH已被充分确立。此外，VEGF调节是协调气道分支与血管生成的上皮-内皮串扰的基础。最近的工作还发现了一个新的作用SHH上皮间质（EMT）的过渡的间皮。相反，上气道软骨和平滑肌之间串扰的分子基础尚不清楚。在这篇综述中，我们研究了组织相互作用和分子串扰的基础上的刻板模式的发展中的肺和介导的损伤修复的现有证据。
Lung development follows a stereotypic program orchestrated by key interactions among epithelial and mesenchymal tissues. Deviations from this developmental program can lead to pulmonary diseases including bronchopulmonary dysplasia and pulmonary hypertension. Significant efforts have been made to examine the cellular and molecular basis of the tissue interactions underlying these stereotypic developmental processes. Genetically engineered mouse models, lung organ culture, and advanced imaging techniques are a few of the tools that have expanded our understanding of the tissue interactions that drive lung development. Intimate crosstalk has been identified between the epithelium and mesenchyme, distinct mesenchymal tissues, and individual epithelial cells types. For interactions such as the epithelial–mesenchymal crosstalk regulating lung specification and branching morphogenesis, the key molecular players, FGF, BMP, WNT, and SHH, are well established. Additionally, VEGF regulation underlies the epithelial–endothelial crosstalk that coordinates airway branching with angiogenesis. Recent work also discovered a novel role for SHH in the epithelial-to-mesenchymal (EMT) transition of the mesothelium. In contrast, the molecular basis for the crosstalk between upper airway cartilage and smooth muscle is not yet known. In this review we examine current evidence of the tissue interactions and molecular crosstalk that underlie the stereotypic patterning of the developing lung and mediate injury repair.
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影响因子：
4.3
作者：
Grzenda A;Shannon J;Fisher J;Arkovitz MS
通讯作者：
Arkovitz MS
影响因子：
4.6
作者：
Domyan, Eric T.;Ferretti, Elisabetta;Sun, Xin
通讯作者：
Sun, Xin
DOI：
10.1073/pnas.0902274106
发表时间：
2009-09-22
影响因子：
11.1
作者：
Harris-Johnson, Kelley S.;Domyan, Eric T.;Sun, Xin
通讯作者：
Sun, Xin
影响因子：
4.6
作者：
Dixit, Radhika;Ai, Xingbin;Fine, Alan
通讯作者：
Fine, Alan
DOI：
10.4049/jimmunol.1001857
发表时间：
2010-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Benjamin JT;Carver BJ;Plosa EJ;Yamamoto Y;Miller JD;Liu JH;van der Meer R;Blackwell TS;Prince LS
通讯作者：
Prince LS