Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation:: Effects on stress hormone levels and adult hippocampal neurogenesis
Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation:: Effects on stress hormone levels and adult hippocampal neurogenesis
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DOI：
10.1016/s0006-3223(02)01457-9
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发表时间：
2002-12-01
影响因子：
10.6
通讯作者：
Keck, ME
中科院分区：
文献类型：
--
作者：
Czéh, B;Welt, T;Keck, ME
背景资料：重复经颅磁刺激越来越多地被用作精神病学的治疗工具，并已被证明可以减弱应激激素系统的活性。应激诱导的成年海马结构重塑可能为理解抑郁症中神经可塑性受损提供细胞基础。因此，逆转结构重塑可能是抗抑郁药治疗的理想目标。本研究探讨了慢性心理社会应激和伴随的重复经颅磁刺激治疗对应激激素调节和海马neuronogenesis.Methods的影响：成年雄性大鼠提交每日心理社会应激和重复经颅磁刺激（20 Hz）18天。采用BrdU免疫组化法检测海马齿状回细胞增殖情况，并检测海马齿状回前体细胞的增殖率和BrdU标记细胞的存活率。为了表征下丘脑-垂体-肾上腺皮质系统的活动，血浆促肾上腺皮质激素和皮质酮浓度进行了measured.Results：慢性心理社会应激导致应激激素水平的显着增加，并有力地抑制了新生成的海马颗粒细胞的增殖率和生存。伴随重复经颅磁刺激治疗使应激诱导的应激激素升高正常化;然而，尽管下丘脑-垂体-肾上腺皮质系统的活动正常化，但重复经颅磁刺激仅轻度减弱海马细胞增殖的减少，而BrdU标记细胞的存活率进一步受到治疗的抑制。这些结果支持下丘脑-垂体-肾上腺皮质系统的衰减是临床观察到的重复经颅磁刺激的抗抑郁作用的重要机制，而本实验设计并未显示重复经颅磁刺激对成人海马神经发生的有益作用。(C)2002生物精神病学学会。
Background: Repetitive transcranial magnetic stimulation is increasingly used as a therapeutic tool in psychiatry and has been demonstrated to attenuate the activity of the stress hormone system. Stress-induced structural remodeling in the adult hippocampus may provide a cellular basis for understanding the impairment of neural plasticity in depressive illness. Accordingly, reversal of structural remodeling might be a desirable goal for antidepressant therapy. The present study investigated the effect of chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation treatment on stress hormone regulation and hippocampal neurogenesis.Methods: Adult male rats were submitted to daily psychosocial stress and repetitive transcranial magnetic stimulation (20 Hz) for 18 days. Cell proliferation in the dentate gyrus was quantified by using BrdU immunohistochemistry, and both the proliferation rate of progenitors and the survival rate of BrdU-labeled cells were evaluated. To characterize the activity of the hypothalamic-pituitary-adrenocortical system, plasma corticotropin and corticosterone concentrations were measured.Results: Chronic psychosocial stress resulted in a significant increase of stress hormone levels and potently suppressed the proliferation rate and survival of the newly generated hippocampal granule cells. Concomitant repetitive transcranial magnetic stimulation treatment normalized the stress-induced elevation of stress hormones; however, despite the normalized activity of the hypothalamic-pituitary-adrenocortical system, the decrement of hippocampal cell proliferation was only mildly attenuated by repetitive transcranial magnetic stimulation, while the survival rate of BrdU-labeled cells was further suppressed by the treatment.Conclusions: These results support the notion that attenuation of the hypothalamic-pituitary-adrenocortical system is an important mechanism underlying the clinically observed antidepressant effect of repetitive transcranial magnetic stimulation, whereas this experimental design did not reveal beneficial effects of repetitive transcranial magnetic stimulation on adult hippocampal neurogenesis. (C) 2002 Society of Biological Psychiatry.