NIR-II fluorescence nanoprobe based on Erbium for fallopian tube diseases diagnosis
NIR-II fluorescence nanoprobe based on Erbium for fallopian tube diseases diagnosis
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DOI：
10.1016/j.matdes.2023.111726
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发表时间：
2023-02-17
影响因子：
8.4
通讯作者：
Gao，Mingyuan
中科院分区：
文献类型：
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作者：
Duan，Guangxin;Wei，Zhuxin;Gao，Mingyuan
输卵管梗阻相关疾病是女性不孕的主要原因。诊断输卵管通畅，准确确定输卵管梗阻病变对不孕症的治疗有重要价值。传统上常用的子宫输卵管造影（HSG）存在放射性危害和假阳性率高的缺点。因此，迫切需要开发一种安全、准确的替代传统输卵管造影诊断输卵管通畅的方法。近年来，第二近红外区荧光成像（NIR-II）因其优异的组织穿透性和信噪比，在活体成像研究中得到了广泛的应用。在荧光剂的帮助下，NIR-II成像具有诊断输卵管通畅的潜力，不幸的是，尚未对此进行探索。本文合成了一种具有优异NIR-II荧光性能的稀土铒基纳米探针（Er-RENPs）。基于Er-RENPs，探讨了NIR-II荧光成像的潜力。结果表明，Er-RENPs可以清晰地显示输卵管轮廓。输卵管狭窄、闭塞、输卵管积水均可诊断。此外，Er-RENPs具有良好的生物相容性。在本研究中，我们报道了NIR-II稀土荧光纳米探针可以作为一种很有前途的荧光剂，在输卵管诊断中具有相当大的应用潜力。
Fallopian tube blockage-related diseases are the main cause of female infertility. Diagnosis of tubal patency and accurate determination of tubal obstruction lesions is of great value for infertility treatment. Conventionally, the common used hysterosalpingogram (HSG) has the disadvantages of radioactive hazard and high false positive rate. Thus, the development of a safe and accurate method which can replace traditional HSG for tubal patency diagnosis is urgently needed. Recently, fluorescence imaging in the second near-infrared region (NIR-II) was widely used inin-vivoimaging research due to its excellent tissue penetration and signal-to noise ratio. With the aid of fluorescence agents, NIR-II imaging has the potential to diagnose tubal patency, which, unfortunately, has not been explored. Herein, a kind of rare-earth Erbium-based nanoprobe (Er-RENPs) with outstanding NIR-II fluorescence property was synthesized. Based on the Er-RENPs, the potential of NIR-II fluorescence imaging was explored. Results show that the outline of fallopian tubes can be clearly visualized with the help of Er-RENPs. And the stenotic, occlusive fallopian tubes and hydrosalpinx can be diagnosed. Additionally, the Er-RENPs exhibit good biocompatibility. In this study, we reported that NIR-II rare-earth fluorescent nanoprobe can serve as a promising fluorescent agent, and exhibits considerable potential application for tubal diagnosis.