Direct Acylation of Aryl Chlorides with Aldehydes by Palladium-Pyrrolidine Co-catalysis
Direct Acylation of Aryl Chlorides with Aldehydes by Palladium-Pyrrolidine Co-catalysis
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DOI：
10.1021/ol101466g
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发表时间：
2010-08-20
期刊：
影响因子：
5.2
通讯作者：
Xiao, Jianliang
中科院分区：
文献类型：
--
作者：
Colbon, Paul;Ruan, Jiwu;Xiao, Jianliang
已开发了一种钯催化剂体系，其允许芳基氯与醛的直接酰化。配体的选择，以及吡咯烷和分子筛的存在下被证明是关键的催化，这似乎是通过烯胺中间体进行。该反应对于宽范围的芳基氯化物是成功的，并且耐受醛组分上的官能度，从而以适度至良好的产率容易地获得烷基芳基酮。
A palladium catalyst system has been developed that allows for the direct acylation of aryl chlorides with aldehydes. The choice of ligand, as well as the presence of pyrrolidine and molecular sieves is shown to be critical to the catalysis, which appears to proceed via an enamine intermediate. The reaction was successful for a wide range of aryl chlorides and tolerant of functionality on the aldehyde component, giving easy access to alkyl aryl ketones in modest to good yields.