Biomaterials-based strategies for salivary gland tissue regeneration.
Biomaterials-based strategies for salivary gland tissue regeneration.
复制标题
DOI：
10.1039/c5bm00358j
复制
发表时间：
2016-04
影响因子：
6.6
通讯作者：
Jia X
中科院分区：
文献类型：
--
作者：
Ozdemir T;Fowler EW;Hao Y;Ravikrishnan A;Harrington DA;Witt RL;Farach-Carson MC;Pradhan-Bhatt S;Jia X
The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to harvest the regenerative potential of stem/progenitor cells found in the adult glands and combine them with biomimetic and cell-instructive materials to assemble implantable tissue modules.
