Design and application of a structured phantom for detection performance comparison between breast tomosynthesis and digital mammography
Design and application of a structured phantom for detection performance comparison between breast tomosynthesis and digital mammography
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DOI：
10.1088/1361-6560/aa5407
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发表时间：
2017-02-07
影响因子：
3.5
通讯作者：
Bosmans, H.
中科院分区：
文献类型：
--
作者：
Cockmartin, L.;Marshall, N. W.;Bosmans, H.
本文介绍并应用了一种插入目标对象的结构化体模，用于比较数字乳腺断层合成摄影（DBT）与2D全视野数字乳腺X射线摄影（FFDM）的检测性能。该体模由一个48 mm厚的胸部形状的聚甲基丙烯酸甲酯（PMMA）容器组成，容器中装有水和不同直径的PMMA球体。插入三维（3D）打印的毛刺肿块（直径范围：3.8-9.7 mm）和非毛刺肿块（1.6-6.2 mm）沿着与微钙化（90-250 μ m）作为目标。接下来，在五种不同的组合FFDM和DBT系统上评估体模，并比较FFDM和DBT模式的目标检测。使用自动曝光控制在这5个系统上采集了FFDM和DBT模式下的10个体模图像。5名阅片人评价了靶点可检测性。采用4-AFC（fouralternative forced-choice）模式读取图像，其中1个节段包括1个靶节段和3个正常背景节段。基于每名阅片员对每种物体类型、尺寸和成像模式的10次试验，评估正确反应（PC）的百分比。此外，通过心理测量曲线的非线性回归拟合评估62.5 PC时的检测阈值直径。重现性研究显示PC值无显著差异。FFDM中靶点检测的评价显示，微钙化检测阈值范围在110 - 118 μ m之间，与DBT中的检测（范围106-158 μ m）相似。在DBT中，与FFDM相比，两种肿块类型的检测率均显著增加（无毛刺和毛刺肿块分别为p = 0.0001和p = 0.0002），几乎100%检测到所有毛刺肿块直径。总之，插入靶的结构体模能够显示五种商业系统的FFDM和DBT模式之间可检测性差异的证据。该体模具有在DBT系统的验收和调试测试中应用于基于任务的评估的潜力。
This paper introduces and applies a structured phantom with inserted target objects for the comparison of detection performance of digital breast tomosynthesis (DBT) against 2D full field digital mammography (FFDM). The phantom consists of a 48 mm thick breast-shaped polymethyl methacrylate (PMMA) container filled with water and PMMA spheres of different diameters. Three-dimensionally (3D) printed spiculated masses (diameter range: 3.8-9.7 mm) and non-spiculated masses (1.6-6.2 mm) along with microcalcifications (90-250 mu m) were inserted as targets.Reproducibility of the phantom application was studied on a single system using 30 acquisitions. Next, the phantom was evaluated on five different combined FFDM & DBT systems and target detection was compared for FFDM and DBT modes. Ten phantom images in both FFDM and DBT modes were acquired on these 5 systems using automatic exposure control. Five readers evaluated target detectability. Images were read with the fouralternative forced-choice (4-AFC) paradigm, with always one segment including a target and 3 normal background segments. The percentage of correct responses (PC) was assessed based on 10 trials of each reader for each object type, size and imaging modality. Additionally, detection threshold diameters at 62.5 PC were assessed via non-linear regression fitting of the psychometric curve. The reproducibility study showed no significant differences in PC values. Evaluation of target detection in FFDM showed that microcalcification detection thresholds ranged between 110 and 118 mu m and were similar compared to the detection in DBT (range of 106-158 mu m). In DBT, detection of both mass types increased significantly (p = 0.0001 and p = 0.0002 for non-spiculated and spiculated masses respectively) compared to FFDM, achieving almost 100% detection for all spiculated mass diameters.In conclusion, a structured phantom with inserted targets was able to show evidence for detectability differences between FFDM and DBT modes for five commercial systems. This phantom has potential for application in task-based assessment at acceptance and commissioning testing of DBT systems.