Deregulation of Rho GTPases in cancer.
Deregulation of Rho GTPases in cancer.
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DOI：
10.1080/21541248.2016.1173767
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发表时间：
2016-07-02
期刊：
影响因子：
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通讯作者：
Malliri A
中科院分区：
文献类型：
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作者：
Porter AP;Papaioannou A;Malliri A
体外和体内研究以及来自人类肿瘤的证据长期以来都表明 Rho GTPase 信号传导与一系列癌症的形成和传播有关。最近，新一代测序已鉴定出人类癌症中 Rho GTP 酶的直接突变。此外，在小鼠模型中消除编码 Rho GTPase 及其调节因子的基因或通过药理学抑制的效果强烈表明，针对 Rho GTPase 信号传导可能构成一种有效的治疗方法。在这篇综述中，我们将探讨人类癌症中 Rho 信号传导失调的各种方式。
In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers. Moreover, the effects of ablating genes encoding Rho GTPases and their regulators in mouse models, or through pharmacological inhibition, strongly suggests that targeting Rho GTPase signaling could constitute an effective treatment. In this review we will explore the various ways in which Rho signaling can be deregulated in human cancers.