Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases
Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases
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DOI：
10.1007/s12265-009-9101-1
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发表时间：
2009-09-01
影响因子：
3.4
通讯作者：
Clegg, Deborah J.
中科院分区：
文献类型：
--
作者：
Nedungadi, Thekkethil P.;Clegg, Deborah J.
在过去的十年中，肥胖症的流行率急剧增加沿着伴随着它所包含的心血管和其他健康风险。分布在腹部内脏中的脂肪组织比皮下脂肪组织具有更大的心血管疾病风险。区域脂肪分布存在性别差异。女性有更多的皮下脂肪，而男性有更多的内脏脂肪。因此，绝经前妇女与肥胖相关的代谢紊乱比男性低得多。外周代谢信号如瘦素和胰岛素参与食物摄入、体重、体脂分布和心血管疾病。大脑中的关键区域，包括下丘脑，整合这些外周肥胖信号以维持整体肥胖水平，这些大脑区域直接受到性激素的影响。因此，心血管疾病的差异可能受到性激素的影响，无论是直接在大脑中还是通过它们对体脂分布的影响。雌激素在调节体脂分布和心血管疾病中的作用是本文的重点。
The prevalence of obesity has dramatically increased over the past decade along with the cardiovascular and other health risks it encompasses. Adipose tissue, which is distributed in the abdominal viscera, carries a greater risk for cardiovascular disorders than adipose tissue subcutaneously. There is a sex difference in the regional fat distribution. Women have more subcutaneous fat, whereas men have more visceral fat. Therefore, obesity-related metabolic disorders are much lower in premenopausal women than men. Peripheral metabolic signals like leptin and insulin are involved in the food intake, body weight, body fat distribution, and cardiovascular disease. Key areas in the brain, including the hypothalamus, integrates these peripheral adiposity signals to maintain overall adiposity levels, and these brain regions are directly influenced by sex hormones. Therefore, differences in cardiovascular disease may be under the influence of sex hormones either directly in the brain or through their influence of body fat distribution. The role of estrogen in mediating body fat distribution and cardiovascular disease is the focus of this review.