Roles of STAT3 defined by tissue-specific gene targeting
Roles of STAT3 defined by tissue-specific gene targeting
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DOI：
10.1038/sj.onc.1203478
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发表时间：
2000-05-15
期刊：
影响因子：
8
通讯作者：
Akira, S
中科院分区：
文献类型：
--
作者：
Akira, S
每个单独的STAT蛋白质的生理作用现在正在通过对“敲除”（KO）小鼠的研究进行检查，这些小鼠携带特定基因的无效等位基因。与出生时存活的其他STAT缺陷小鼠相比，STAT 3缺陷小鼠在早期胚胎发生期间死亡。然而，可以通过利用Cre-loxP重组系统在以后的生活中消除该基因来评估STAT 3在成年组织中的作用。对组织特异性STAT 3缺陷小鼠的分析表明，STAT 3在多种生物学功能中起着至关重要的作用，包括细胞生长、抑制和诱导凋亡以及细胞运动。
The physiological role of each individual STAT protein is now being examined through the study of 'knockout' (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis, However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility.