Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.
Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.
复制标题
禽类海马体的长期增强不需要激活 N-甲基-D-天冬氨酸 (NMDA) 受体。
DOI：
10.1002/syn.890130208
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Ball,GF
中科院分区：
文献类型：
--
作者：
Wieraszko,A;Ball,GF
从鸽子海马切片记录的诱发电位可逆衰减2 mM犬尿烯酸。高频刺激（3 × 200 Hz，持续1秒，间隔1秒）诱发诱发电位持续增加，以非递减形式持续至少2小时。NMDA受体拮抗剂（APV和MK-801）未阻断这种电位幅度的增加。这些数据表明，在鸽子海马中观察到的突触易化似乎是一种长时程增强，并不依赖于NMDA受体的激活。© 1993 Wiley利斯公司
Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 × 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK‐801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long‐term potentiation, does not depend on the activation of NMDA receptors. © 1993 Wiley‐Liss, Inc.