IMMUNOLOGICAL RELATIONSHIPS AMONG SPECIES AND STRAINS OF VIRULENT TREPONEMES AS DETERMINED WITH THE TREPONEMAL IMMOBILIZATION TEST
IMMUNOLOGICAL RELATIONSHIPS AMONG SPECIES AND STRAINS OF VIRULENT TREPONEMES AS DETERMINED WITH THE TREPONEMAL IMMOBILIZATION TEST
复制标题
DOI：
10.1093/oxfordjournals.aje.a119455
复制
发表时间：
1951-01-01
影响因子：
--
通讯作者：
TURNER, TB
中科院分区：
文献类型：
--
作者：
KHAN, AS;NELSON, RA;TURNER, TB
本文探讨了家兔梅毒、雅司病与性病螺旋体病的免疫学关系。通过使用由纳尔逊和迈耶开发的用于固定抗体的试验。还研究了4株梅毒螺旋体之间的免疫学关系。用3株弓形虫感染家兔血清，pertenue和两株T. cuniculi用于固定针对T.苍白球在这3组密螺旋体之间显示出显著的交叉反应性。用4株T. pallidum与Nichols株T.苍白球相反，对T. pallidum、T. pertenue和T.兔血清用Reiter、Kazan和S-26株无毒力的可培养螺旋体免疫。用固定化抗体定量滴定法测定了弓形虫感染家兔血清中的抗体。苍白球T pertenue或T.用同源和异源种属进行家兔试验。密螺旋体结果表明，尽管存在交叉反应性，但T。cuniculi和T. pertenue和T.另一边是苍白球相似的定量滴定表明两株T. pertenue和T.苍白球4株T.苍白球：第4菌株（St.Louis）显示出明显更高的同源固定滴度和对所有其它3种菌株的一致低的异源固定反应性。在这些expts。定量固定试验在2 - 3倍范围内是可重复的。
Immunological relationship between syphilis, yaws and venereal spirochetosis of rabbits were detd. by use of the test for immobilizing antibodies developed by Nelson and Mayer. The immunological relationships between 4 strains of Treponema pallidum were also studied. Sera from rabbits infected with 3 strains of T. pertenue and two strains of T. cuniculi for immobilizing reactivity against the Nichols strain of T. pallidum demonstrated a significant cross-reactivity between these 3 groups of treponemes. Sera from rabbits infected with 4 strains of T. pallidum demonstrated a similar cross-reaction between all of those and the Nichols strain of T. pallidum. Conversely, there was an absence of immobilizing activity against T. pallidum, T. pertenue and T. cuniculi, of sera from rabbits immunized with Reiter, Kazan and S-26 strains of non-virulent, cultivatable spirochetes. Quantitative titrations of immobilizing antibody in sera from rabbits infected with T. pallidum T. pertenue or T. cuniculi were performed with homologous and heterologous spp. of treponemes. The results showed that, although cross-reactivity is present, a definitive antigenic difference exists between T. cuniculi on the one hand, and T. pertenue and T. pallidum on the other. Similar quantitative titrations demonstrated a high-cross reactivity between 2 strains of T. pertenue and the Nichols strain of T. pallidum. No significant differences were observed between the reciprocal homologous and heterologous immobilizing titers of 3 of 4 strains of T. pallidum: the 4th strain (St. Louis) showed a significantly higher homologous immobilizing titer and a consistently low heterologous immobilizing reactivity against all the other 3 strains. In these expts. the quantitative immobilization test was reproducible within a 2- to 3-fold range.