Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis.
Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis.
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DOI：
10.1097/psy.0b013e318230343f
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发表时间：
2011-10
影响因子：
3.3
通讯作者：
Kirkpatrick B
中科院分区：
文献类型：
--
作者：
Fernandez-Egea E;García-Rizo C;Miller B;Parellada E;Justicia A;Bernardo M;Kirkpatrick B
精神分裂症与年龄相关的异常有关，包括糖耐量异常、脉压升高、炎症增加、干细胞信号异常和端粒长度缩短。这些代谢异常以及其他研究结果表明，精神分裂症和相关疾病可能与加速衰老有关。睾酮活性随着年龄的增长而逐渐下降。我们检验了新诊断的antipsychotic-naïve男性非情感性精神病患者的循环生物活性睾酮低于匹配对照受试者的假设。患者（n=33）与对照组（n=33）在年龄、性别、体重指数、原籍家庭社会经济状况和吸烟情况方面进行匹配。游离雄激素指数（FAI）是衡量生物活性睾酮的指标，精神病组的游离雄激素指数（FAI）[平均57.7%，SD=26.1]显著低于对照组[71.6%,27.0；P =0.04]，效应量为0.53。多变量分析也支持这一发现。在精神病组中，FAI与概念障碍项呈显著负相关（r=-0.35, p=0.049），但与现实扭曲（r=-0.21; p=0.24）、阴性症状（r=0.004; p=0.98）或抑郁（r=-0.014; p=0.94）无显著负相关。低睾丸激素与非情感性精神病的加速衰老是一致的，但需要对这一假设进行进一步的测试。
Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signalling and shorter telomere length. These metabolic abnormalities as well as other findings suggest schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naïve male patients with nonaffective psychosis than in matched control subjects. Patients (n=33) were matched to control subjects (n=33) for age, gender, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index (FAI), a measure of biologically active testosterone, was significantly lower in the psychosis group [mean 57.7%, SD=26.1] than in control subjects [71.6%, 27.0; p=0.04], with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, FAI had a significant negative correlation with the conceptual disorganization item (r=-0.35, p=0.049), but not with reality distortion (r=-0.21; p=0.24), negative symptoms (r=0.004; p=0.98) or depression (r=-0.014; p=0.94). Lower testosterone is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.