Kinesin's network of chemomechanical motor cycles
Kinesin's network of chemomechanical motor cycles
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DOI：
10.1103/physrevlett.98.258102
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发表时间：
2007-06-22
影响因子：
8.6
通讯作者：
Lipowsky, Reinhard
中科院分区：
文献类型：
--
作者：
Liepelt, Steffen;Lipowsky, Reinhard
一个通用的网络理论的分子马达驱动蛋白的开发是基于不同的化学状态的电机和最近的观察其机械步骤。对于低浓度的腺苷二磷酸（ADP），电机的行为是由两个化学机械的摩托车周期，决定电机的失速力的竞争。第三个循环对于大ADP浓度变得重要。该理论提供了一个定量描述的功能依赖性不同的电机性能在单分子实验中观察到的。
A general network theory for the molecular motor kinesin is developed that is based on the distinct chemical states of the motor and on recent observations about its mechanical steps. For small concentrations of adenosine diphosphate (ADP), the motor's behavior is governed by the competition of two chemomechanical motor cycles which determine the motor's stall force. A third cycle becomes important for large ADP concentrations. The theory provides a quantitative description for the functional dependencies of different motor properties as observed in single molecule experiments.