The neuroanatomy of post-polio fatigue.
The neuroanatomy of post-polio fatigue.
复制标题
脊髓灰质炎后疲劳的神经解剖学。
DOI：
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发表时间：
1994
影响因子：
4.3
通讯作者：
N. M. Frick
中科院分区：
文献类型：
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作者：
R. L. Bruno;Cohen Jm;T. Galski;N. M. Frick
疲劳是最常见的报告，最衰弱，最了解脊髓灰质炎后后遗症（PPS）。50年前的尸检研究记录了网状激活系统（RAS）内频繁和严重的脊髓灰质炎病毒诱导的病变。最近，神经心理学测试记录了脊髓灰质炎幸存者报告严重疲劳的明显注意力缺陷。然而，这两项发现都与脊髓灰质炎后疲劳的病理生理学无关。对22名脊髓灰质炎幸存者进行了脑部磁共振成像，这些幸存者经过仔细筛选以消除合并症的影响。受试者对他们日常疲劳的严重程度以及注意力、认知和记忆方面的主观问题进行评分。在55%报告高度疲劳的受试者中，网状结构、壳核、内侧蹄回或白色物质束中的小离散或多个点状高信号（HS）区域成像，而在报告低度疲劳的受试者中无一例成像。HS的存在与疲劳严重程度和注意力、集中力、保持清醒、近期记忆和清晰思维方面的主观问题显著相关。HS或疲劳严重程度与年龄、急性脊髓灰质炎严重程度、抑郁症状或睡眠困难之间缺乏显著相关性，不利于这些因素引起HS或产生疲劳。这些初步研究结果表明，脊髓灰质炎病毒诱导的脑激活系统损伤可能是脊髓灰质炎幸存者报告的主观疲劳和注意力缺陷的基础。
Fatigue is the most commonly reported, most debilitating, and most poorly understood Post-Polio Sequelae (PPS). Postmortem studies of 50 years ago documented frequent and severe poliovirus-induced lesions within the Reticular Activating System (RAS). Recently, neuropsychological testing has documented marked attention deficits in polio survivors reporting severe fatigue. However, neither of these findings has yet been related to the pathophysiology of post-polio fatigue. Magnetic resonance imaging of the brain was performed in 22 polio survivors carefully screened to eliminate the effect of comorbidities. Subjects rated the severity of their daily fatigue and subjective problems with attention, cognition, and memory. Small discrete or multiple punctate areas of hyperintense signal (HS) in the reticular formation, putamen, medial leminiscus, or white matter tracts were imaged in 55% of the subjects reporting high fatigue and in none of those reporting low fatigue. The presence of HS significantly correlated with fatigue severity and subjective problems in attention, concentration, staying awake, recent memory, and thinking clearly. The lack of significant correlations between HS or fatigue severity and age, severity of the acute polio, depressive symptoms, or difficulty sleeping militates against these factors as either causing HS or producing fatigue. These preliminary findings suggest that poliovirus-induced lesions in the Brain Activating System may underlie the subjective fatigue and attention deficits reported by polio survivors.
脑白质疏松症受试者的神经心理学测试结果。
影响因子：
--
作者：
Rao,SM;Mittenberg,W;Bernardin,L;Haughton,V;Leo,GJ
通讯作者：
Leo,GJ