Antioxidative Coumarins from the Roots of Ferulago subvelutina
Antioxidative Coumarins from the Roots of Ferulago subvelutina
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DOI：
10.14233/ajchem.2013.13208
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发表时间：
2013-04-01
影响因子：
--
通讯作者：
Gohari, A. R.
中科院分区：
文献类型：
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作者：
Naseri, M.;Monsef-Esfehani, H. R.;Gohari, A. R.
从伞形科阿魏（Ferulago subvelutina）根的乙酸乙酯提取物中分离得到6个香豆素类化合物，分别为欧前胡素（1）、oxypeucedanin（2）、xanthotoxin（3）、异欧前胡素（4）、oxypeucedanin hydrate（5）、meranzine hydrate（6）和1个甾醇，即β-谷甾醇亚油酸酯（7）。采用DPPH自由基清除法测定化合物的抗氧化活性。化合物表现出适度的抗氧化活性。化合物对DPPH自由基的清除能力低于合成抗氧化剂叔丁基羟基甲苯（BHT）（IC 50 = 27 μ g/mL），其顺序为BHT >氧化前胡素水合物> meranzin水合物>氧化前胡素>异欧前胡素>花椒毒素>蛇床子素。
From the ethyl acetate extract of the roots of Ferulago subvelutina (Apiaceae) six coumarins, osthol (1), oxypeucedanin (2), xanthotoxin (3), isoimperatorin (4), oxypeucedanin hydrate (5), meranzine hydrate (6) and one sterol, beta-sitosteryl linoleate (7), were isolated by silica gel column chromatography and identified by spectroscopic methods. Antioxidant activities of the isolated compounds were tested by the DPPH radical scavenging assay. Compounds exhibited moderate antioxidant activities. DPPH scavenging abilities of compounds were lower than that of synthetic antioxidant tert-butyl hydroxytoluene (BHT) (IC50 = 27 mu g/mL) in the order BHT > oxypeucedanin hydrate > meranzin hydrate > oxypeucedanin > isoimperaturin > xanthotoxin > osthole.