Smoking and lung cancer with special regard to type of smoking and type of cancer. A case-control study in north Sweden.
Smoking and lung cancer with special regard to type of smoking and type of cancer. A case-control study in north Sweden.
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DOI：
10.1038/bjc.1986.111
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发表时间：
1986-05
影响因子：
8.8
通讯作者：
Larsson LG
中科院分区：
文献类型：
--
作者：
Damber LA;Larsson LG
一项病例对照研究阐明了吸烟的病因学作用，该研究包括 1972 年至 1977 年间在瑞典北部登记的 579 例男性肺癌病例。在该系列中，吸烟引起的人群病因比例约为 80%。吸烟斗与吸烟一样常见，并且具有相似的相对风险。然而，吸烟斗病例在诊断时的平均年龄和平均吸烟年数明显高于吸烟病例。吸烟和吸烟斗都发现了明显的剂量反应关系。对于戒烟者来说，从戒烟五年起，相对风险逐渐下降。然而，与戒烟者相比，戒烟者的这种下降幅度要小得多。小细胞癌和鳞状细胞癌的相对风险较高。对于腺癌，相对风险要低得多，但仍然显着增加。使用两种类型的对照，即减少对照和活对照。与活着的对照相比，与已故对照相比，通常给出更高的风险估计。
The aetiologic role of tobacco smoking was elucidated in a case-control study comprising 579 cases of male lung cancer registered during 1972-1977 in northern Sweden. The population aetiologic fraction attributable to smoking was about 80% in this series. Pipe smoking was as common as cigarette smoking and gave similar relative risk. The pipe smoking cases, however, had significantly higher mean age and mean smoking years at the time of diagnosis than the cigarette smoking cases. An obvious dose-response relation was found for both cigarette and pipe smoking. In ex-smokers, the relative risk gradually decreased from five years after cessation of smoking. This decrease was, however, much less pronounced in ex-pipe smokers than in ex-cigarette smokers. High relative risks were obtained for small cell and squamous cell carcinomas. For adenocarcinomas the relative risk was considerably lower but still significantly increased. Two types of controls were used, i.e. decreased and living. Comparison with living controls gave generally higher risk estimates than comparison with deceased controls.