Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer
Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer
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DOI：
10.1002/jcb.10661
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发表时间：
2004-02-15
影响因子：
4
通讯作者：
Heston, WDW
中科院分区：
文献类型：
--
作者：
Ghosh, A;Heston, WDW
前列腺特异性膜抗原（PSMA）是一种独特的膜结合糖蛋白，在前列腺癌和大多数实体瘤的新生血管中过表达，但在正常组织的血管中不表达。PSMA的这种独特表达使其成为重要的标志物以及成像剂的大细胞外靶标。PSMA可以用作递送治疗剂如细胞毒素或放射性核素的靶标。PSMA具有两种独特的酶功能，叶酸水解酶和NAALAD酶，并且发现其像其他膜结合受体一样通过网格蛋白包被的凹坑再循环。PSMA的内化性质导致人们考虑PSMA的天然配体的潜在存在。本文就PSMA在细胞内的表达调控及其在前列腺癌及其转移中的意义作一综述。(C)2003 Wiley-Liss，Inc.
Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an important marker as well as a large extracellular target of imaging agents. PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides. PSMA has two unique enzymatic functions, folate hydrolase and NAALADase and found to be recycled like other membrane bound receptors through clathrin coated pits. The internalization property of PSMA leads one to consider the potential existence of a natural ligand for PSMA. In this review we have discussed the regulation of PSMA expression within the cells, and significance of its expression in prostate cancer and metastasis. (C) 2003 Wiley-Liss, Inc.