Immune intervention studies in insulin-dependent diabetes mellitus.
Immune intervention studies in insulin-dependent diabetes mellitus.
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胰岛素依赖型糖尿病的免疫干预研究。
DOI：
10.1002/dmr.5610030410
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Skyler,JS
中科院分区：
文献类型：
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作者：
Skyler,JS
I型或胰岛素依赖型糖尿病（IDDM）发病机制的确切机制仍不确定，但目前仍是许多研究的主题。目前流行的配方包括使个体易患IDDM的遗传决定的素质（致糖尿病基因）、由环境因素（病毒感染和/或化学毒素）引发的胰岛细胞损伤和免疫介导的胰岛β细胞破坏。遗传素质涉及HLA系统，如本文其他地方所述。然而，致糖尿病基因是否存在于HLA区域内或其附近，或者是否存在由特定HLA相关基因赋予的定量易感性，仍不确定，如Nerup等人所建议的。有令人信服的证据表明，它们可以启动遗传易感动物的发病过程^，但它们在人类胰岛素依赖型糖尿病中的作用的证据不太可靠。虽然有人认为，胰岛素依赖型糖尿病的实质性不一致，
The precise mechanisms involved in the etiopathogenesis of type I or insulin-dependent diabetes mellitus (IDDM) remain uncertain but are the subject of much current investigation. A popular current formulation includes genetically determined diatheses that predispose the individual to IDDM (diabetogenic genes), islet cell damage triggered by environmental factors (viral infections andlor chemical toxins), and immunologically mediated islet beta-cell destruction. The genetic diathesis involves the HLA system, as has been reviewed elsewhere in this Yet, it remains uncertain as to whether diabetogenic genes exist either within the HLA region or in close proximity thereto or whether there is rather a quantitative susceptibility conferred by particular HLA-related genes, as suggested by Nerup et al. I Whether environmental events are important in the pathogenetic sequence is unresolved. There is compelling evidence that they may initiate the pathogenetic processes in genetically predisposed animal^,^ but the evidence for their role in IDDM in human beings is less secure. Although it has been argued that the substantial discordance of IDDM in