HUMAN REISSNERS MEMBRANE IN PATIENTS WITH AGE-RELATED NORMAL HEARING AND WITH SENSORINEURAL HEARING-LOSS
HUMAN REISSNERS MEMBRANE IN PATIENTS WITH AGE-RELATED NORMAL HEARING AND WITH SENSORINEURAL HEARING-LOSS
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DOI：
10.1159/000276381
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发表时间：
1993-03-01
期刊：
影响因子：
--
通讯作者：
GLEESON, MJ
中科院分区：
文献类型：
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作者：
DEFRAISSINETTE, A;FELIX, H;GLEESON, MJ
对6例年龄相关性正常听力(ARNH)和4例各种原因所致感音神经性耳聋(SNHL)患者的Reissner膜形态特征进行了研究。该膜由上皮、基底膜和含有黑素细胞的间皮组成。上皮细胞有两种主要形式：扁平和圆形。在所有标本中，圆形细胞形成轮状、簇状、链状和条带。在底部回旋时，条带较宽，轮缘较大，向顶端逐渐变小。黑素细胞的数量在底圈的上半部和中圈的下半部都是其余旋转的2-4倍。在SNHL患者的标本中，黑素细胞的数量和簇数均多于ARNH组，且中转角上半部和顶转角的黑素细胞数高于ARNH组。上皮细胞、间皮细胞和黑素细胞的超微结构检查显示SNHL患者比ARNH患者更明显的细胞变性。讨论了Reissner膜结构改变与感觉神经变性之间的可能联系。
Morphological features of Reissner's membrane were investigated in 6 patients with age-related normal hearing (ARNH) and in 4 with sensorineural hearing loss (SNHL) stemming from various causes. The membrane consisted of an epithelium, a basement membrane and a mesothelium with melanocytes. There were two major forms of epithelial cells: flat and rounded. In all specimens, the rounded cells formed whorls, clusters, strands and bands. The bands were wider and the whorls larger in the basal turn and decreased gradually in size toward the apex. The number of melanocytes was 2-4 times higher in both the upper half of the basal turn and the lower half of the middle turn than in the rest of the turns. In specimens from patients with SNHL, whorls and clusters were both more numerous and larger, and the number of melanocytes was higher in the upper half of the middle turn and in the apical turn than that in the ARNH group. Ultrastructural examination of epithelial and mesothelial cells as well as of melanocytes showed more pronounced cellular degeneration in patients with SNHL than in those with ARNH. A possible correlation between structural alterations of Reissner's membrane and sensorineural degeneration is discussed.