Decoding the RNA structurome.
Decoding the RNA structurome.
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DOI：
10.1016/j.sbi.2016.01.007
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发表时间：
2016-02
影响因子：
6.8
通讯作者：
Chang HY
中科院分区：
文献类型：
--
作者：
Lu Z;Chang HY
RNA 分子的结构对其结构、调节和催化功能至关重要。高通量测序的最新进展使得在转录组范围内探测 RNA 结构的方法得以开发——称为 RNA 结构组。在这里，我们回顾了探测 RNA 结构组的最先进技术，并重点介绍了从这些研究中获得的见解。我们还指出了当前方法的局限性，并讨论了未来改进的潜在方向。
Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for probing RNA structures on a transcriptome-wide scale – termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.