Beta-carotene decreases markers of lipid peroxidation in healthy volunteers.
Beta-carotene decreases markers of lipid peroxidation in healthy volunteers.
复制标题
β-胡萝卜素可降低健康志愿者的脂质过氧化标志物。
DOI：
10.1080/01635589309514251
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Sugerman,S
中科院分区：
文献类型：
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作者：
Gottlieb,K;Zarling,EJ;Mobarhan,S;Bowen,P;Sugerman,S
我们之前的研究表明，每日摄入β -胡萝卜素（一种无毒的抗氧化剂）可以通过血清脂质过氧化水平来降低脂质过氧化。另一种检测脂质过氧化的方法是测量呼吸中的戊烷。戊烷是一种五碳碳氢化合物，当ω - 6不饱和脂肪酸发生过氧化反应时释放出来。本研究的目的是观察β -胡萝卜素的分级剂量是否会影响正常受试者在两周内不含类胡萝卜素的液体饮食中呼吸戊烷的排泄。然后，受试者每天补充15毫克（n = 7）或120毫克（n = 8）的β -胡萝卜素，持续四周，同时继续相同的饮食。再喂β -胡萝卜素前后测定血清β -胡萝卜素和呼吸戊烷。脂质过氧化作用，通过气相色谱测定呼气戊烷，显著（p < 0.05）减少了每天补充120毫克β -胡萝卜素（从3.7±0.9到2.2 + 1.4 nmol/l）。然而，15 mg β -胡萝卜素剂量组戊烷呼出量的下降没有达到统计学意义（p = 0.13）。
We previously showed that daily intake of β‐carotene, a nontoxic antioxidant, reduces lipid peroxidation as assessed by serum lipid peroxide levels. An alternative method to detect lipid peroxidation is the measurement of pentane in breath. Pentane is a five‐carbon hydrocarbon that is released when an omega‐6 unsaturated fatty acid undergoes peroxidation. The aim of this study was to see whether graded doses of β‐carotene would affect breath pentane excretion in normal subjects placed on a carotenoid‐free liquid diet for two weeks. The subjects were then repleted with either 15 (n = 7) or 120 mg (n = 8) of β‐carotene daily for four weeks while continuing the same diet. Serum β‐carotene and breath pentane were measured before and after β‐carotene refeeding. Lipid peroxidation, as assessed by gas‐chromatographic measurement of breath pentane, was significantly (p < 0.05) reduced by daily supplements of 120 mg β‐carotene (from 3.7 ± 0.9 to 2.2 + 1.4 nmol/l). However, the decline in pentane exhalation observed with the 15‐mg β‐carotene dose did not achieve statistical significance (p = 0.13).