Effect of cochlear implantation on residual spiral. ganglion cell count as determined by comparison with the contralateral nonimplanted inner ear in humans
Effect of cochlear implantation on residual spiral. ganglion cell count as determined by comparison with the contralateral nonimplanted inner ear in humans
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DOI：
10.1177/000348940511400508
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发表时间：
2005-05-01
影响因子：
1.4
通讯作者：
Nadol, JB
中科院分区：
文献类型：
--
作者：
Khan, AM;Handzel, O;Nadol, JB
通常认为，至少最小数量的螺旋神经节细胞对于人工耳蜗的成功语音感知是必不可少的。虽然多通道人工耳蜗植入体的插入经常导致植入耳的残余听力丧失，但这一结果并不意味着螺旋神经节细胞的残余群体已发生显著损伤。本研究的目的是比较螺旋神经节细胞计数的植入和非植入的耳蜗在11例患者的两个颞骨是可用的，其中多通道人工耳蜗植入体已被放置在单侧。通过标准技术处理颞骨用于光学显微镜检查。用二维方法重建耳蜗。通过配对t检验（双尾）比较植入侧和非植入侧的螺旋神经节细胞计数。在耳蜗最基底的三个节段中，植入耳和非植入耳的平均螺旋神经节细胞计数没有统计学差异。然而，植入耳蜗的第4段（顶段）的平均螺旋神经节细胞计数和平均总螺旋神经节细胞计数低于未植入耳蜗（p <0.01）。本研究的结果表明，与非植入耳相比，植入耳的螺旋神经节细胞总数略有减少，主要是在顶段。这一发现的可能解释进行了讨论。
It is generally assumed that at least a minimal number of spiral ganglion cells is essential for successful speech perception with a cochlear implant. Although the insertion of a multichannel cochlear implant frequently results in loss of residual hearing in the implanted ear, this outcome does not imply that significant damage to residual populations of spiral ganglion cells has occurred. The purpose of the current study was to compare spiral ganglion cell counts in implanted and nonimplanted cochleas in 11 patients for whom both temporal bones were available and in whom a multichannel cochlear implant had been placed unilaterally. The temporal bones were processed for light microscopy by standard techniques. The cochleas were reconstructed by 2-dimensional methods. Spiral ganglion cell counts of the implanted and nonimplanted sides were compared by a paired t-test (2-tailed). The mean spiral ganglion cell counts for implanted and nonimplanted ears were not statistically different in the most basal three segments of the cochlea. However, the mean spiral ganglion cell count in segment 4 (apical segment) and the mean total spiral ganglion cell count were lower in the implanted cochleas than in the nonimplanted cochleas (p < .01 ). The results of this study suggest a modest decrease in the total spiral ganglion cell count in the implanted ears as compared to the nonimplanted ears, principally in the apical segment. Possible interpretations of this finding are discussed.