The effects of orchiopexy on serum anti-Mullerian hormone levels in unilateral cryptorchid infants
The effects of orchiopexy on serum anti-Mullerian hormone levels in unilateral cryptorchid infants
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DOI：
10.1007/s00383-006-1646-3
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发表时间：
2006-03-01
影响因子：
1.8
通讯作者：
Mutus, M
中科院分区：
文献类型：
--
作者：
Demircan, M;Akinci, A;Mutus, M
背景/目的：在男性中，血清抗苗勒管激素（AMH）反映了支持细胞的功能，并提供了精管完整性的估计。有人建议，手术前后AMH水平的比较可能有助于确定治疗的有效性。在这项研究中，我们测定了单侧隐睾婴儿在睾丸切除术前后的血清AMH水平，并将这些数据与年龄匹配的对照组的AMH值进行了比较。方法：研究人群为20例单侧可触及睾丸的隐睾患儿，行睾丸切除术作为隐睾组，20例健康患儿行包皮环切术作为对照组。所有的孩子都是12个月大。在手术前（12个月）和手术后6个月（18个月）测定血清AMH水平。结果与结论：术中发现所有隐睾大小正常，均位于腹股沟浅囊或腹股沟皮下。在术前血清AMH水平方面，隐睾组与对照组比较差异有统计学意义（40.04 +/- 4.97 ng/ml vs 53.46 +/- 7.51 ng/ml） （P < 0.05）。同样，隐睾患儿术后血清AMH水平低于对照组（39.27 +/- 4.58 ng/ml vs 52.79 +/- 6.27 ng/ml） （P < 0.05）。在隐睾患儿中，睾丸切除术后6个月测定的血清AMH水平与术前基础水平相似（40.04 +/- 4.97 ng/ml vs 39.27 +/- 4.58 ng/ml） （P < 0.05）。1岁时行睾丸切除术后6个月，单侧可触及的隐睾患儿AMH水平保持不变。这是文献中首次报道睾丸切除术对血清AMH水平的影响。
Background/Purpose: In males, serum anti-Mullerian hormone (AMH) reflects Sertoli cell function and provides an estimate of seminiferous tubular integrity. It has been suggested that comparison of AMH levels before and after surgery could be useful to determine effectiveness of the treatment. In this study, we determined the serum AMH levels in infants with unilateral cryptorchidism before and after orchiopexy procedure and compared these data with the AMH values in age-matched controls. Methods: The study population was 20 cryptorchid children with unilateral palpable testes who underwent orchiopexy as a cryptorchid group, and 20 healthy children who underwent circumcision as a control group. All children are 12 months of age. Serum AMH levels were measured at just before surgery (at 12 month old) and 6 months after surgery (at 18 month old). Results and Conclusions: All undescended testes were found to be normal in size and in the superficial inguinal pouch or subcutaneous region of the groin at surgery. With regard to the preoperative serum AMH levels, there was a significant difference between the cryptorchid and the control groups (40.04 +/- 4.97 ng/ml versus 53.46 +/- 7.51 ng/ml) (P < 0.05). Similarly, the postoperative serum AMH levels were lower in cryptorchid children than in controls (39.27 +/- 4.58 ng/ml versus 52.79 +/- 6.27 ng/ml) (P < 0.05). In cryptorchid children, serum AMH levels measured at 6 months after orchiopexy were similar with preoperative basal levels (40.04 +/- 4.97 ng/ml versus 39.27 +/- 4.58 ng/ml) (P > 0.05). AMH levels in children with unilateral palpable undescended testes remain unchanged 6 months after orchiopexy performed at 1 year of age. This is the first report in literature regarding the effect of orchiopexy on the serum AMH levels.