Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma
Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma
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DOI：
10.1007/s00428-011-1140-8
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发表时间：
2011-10-01
期刊：
影响因子：
3.5
通讯作者：
Aozasa, Katsuyuki
中科院分区：
文献类型：
--
作者：
Zaki, Mona A. A.;Wada, Naoki;Aozasa, Katsuyuki
探讨肿瘤相关巨噬细胞（tam）在经典霍奇金淋巴瘤（CHL）预后中的作用。用免疫组织化学方法检测82例CHL患者TAMs、CD68、HLA-DR、CD163、HLA-DR/CD68 （M1）、CD163/CD68 （M2）标志物的表达。统计阳性染色细胞数，分析tam数量与患者生存时间的相关性。CD163+细胞和M2细胞数量与总生存期缩短有显著相关性（P < 0.05）， CD68+细胞数量与总生存期缩短无显著相关性（P = 0.0827）。HLA-DR +细胞和M1细胞与总生存率无显著相关性。当局限于混合细胞亚型时，M1细胞数量与预后良好相关（P < 0.05）， M2细胞数量与预后良好无关（P = 0.7）。年龄较大、男性是影响预后的不利因素。在多因素分析中，CD163+细胞数、M2+细胞数和年龄是总生存率差的独立因素（P分别为0.03、0.02和0.01）。CD163+细胞和M2细胞可能在CHL中起肿瘤促进作用。混合细胞型M1细胞可能具有抑瘤作用。
To evaluate roles of tumor-associated macrophages (TAMs) for prognosis of classical Hodgkin lymphoma (CHL). Expression of markers for TAMs, CD68, HLA-DR, CD163, HLA-DR/CD68 (M1), and CD163/CD68 (M2) was immunohistochemically examined in 82 cases with CHL. Positively stained cells were counted and correlation of number of TAMs and patients' survival time was analyzed. Number of CD163+ cells and M2 cells was significantly correlated with shorter overall survival (P < 0.05), while it was marginally significant for CD68+ cells (P = 0.0827). HLA-DR + cells and M1 cells showed no significant correlation with overall survival. When confined to mixed cellularity subtype, number of M1 cells was correlated with favorable prognosis (P < 0.05), while M2 did not (P = 0.7). Older age and male sex were unfavorable factors for prognosis. At multivariate analysis, number of CD163+ cells, M2+ cells, and age were independent factors for poor overall survival (P = 0.03, 0.02, and 0.01, respectively). CD163+ cells and M2 cells might work to be tumor promotive in CHL. M1 cells might be tumor suppressive in mixed cellularity type.