Protein complexes regulating Arp2/3-mediated actin assembly
Protein complexes regulating Arp2/3-mediated actin assembly
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DOI：
10.1016/j.ceb.2005.12.003
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Scita, G
中科院分区：
文献类型：
--
作者：
Stradal, TEB;Scita, G
调节肌动蛋白动力学的关键步骤是肌动蛋白丝的从头成核和伸长，这可以由有限数量的蛋白质和蛋白质复合物催化。其中Arp 2/3复合物和formins研究得最好。Arp 2/3复合物活性通过与成核促进因子（如WASP/WAVE家族蛋白）的信号依赖性关联来控制。这些分子的一个共同主题是，它们通过形成大的多分子复合物，作为各种信号通路的同步检测器，这对于WAVE来说是确定的，但对于WASP来说才刚刚开始出现。
Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.