Predictors of delayed gastric emptying in diabetes
Predictors of delayed gastric emptying in diabetes
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DOI：
10.2337/diacare.24.7.1264
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发表时间：
2001-07-01
期刊：
影响因子：
16.2
通讯作者：
Horowitz, M
中科院分区：
文献类型：
--
作者：
Jones, KL;Russo, A;Horowitz, M
目的 - 确定糖尿病患者胃排空率的预测因素。 研究设计和方法 - 共有 101 名门诊糖尿病患者（79 名 1 型和 22 名 2 型）接受了固体/液体膳食胃排空（闪烁扫描）、上消化道症状（问卷）、血糖控制（胃排空测量期间的血糖浓度）和自主神经功能（心血管）的测量。结果 - 66 名 (65%) 患者的胃固体和/或液体排空延迟。女性的固体（100 分钟滞留 64 +/- 3.2 对比 50.2 +/- 3.6%，P < 0.005）和液体（100 分钟滞留 22.7 +/- 1.7 对比 16.0 +/- 1.8%，P < 0.001）胃排空速度慢于男性。在所有上消化道症状（包括恶心和呕吐）中，只有腹胀/饱腹感与胃排空缓慢相关（P < 0.005）。多元回归分析表明。腹胀/饱腹感和女性都是固体和液体胃排空较慢的预测因素。结论 - 我们的结论是，腹胀/饱腹感的存在而不是任何其他上消化道症状与糖尿病性胃轻瘫相关，并且糖尿病女性的胃排空速度比糖尿病男性慢。
OBJECTIVE - To define the predictors of the rate of gastric emptying in patients with diabetes.RESEARCH DESIGN AND METHODS - A total of 101 outpatients with diabetes (79 type 1 and 22 type 2) underwent measurements of gastric emptying of a solid/liquid meal (scintigraphy), upper gastrointestinal symptoms (questionnaire), glycemic control (blood glucose concentrations during gastric emptying measurement), and autonomic nerve function (cardiovascular reflexes).RESULTS - The gastric emptying of solid and/or liquid was delayed in 66 (65%) patients. Solid (retention at 100 min 64 +/- 3.2 vs. 50.2 +/- 3.6%, P < 0.005) and liquid (retention at 100 min 22.7 +/- 1.7 vs. 16.0 +/- 1.8%, P < 0.001) gastric emptying was slower in women than in men. Of all upper gastrointestinal symptoms (including nausea and vomiting), only abdominal bloating/fullness was associated with slower gastric emptying (P < 0.005). A multiple regression analysis demonstrated. that both abdominal bloating/fullness and female sex were predictors of slower gastric emptying of both solids and liquids.CONCLUSIONS - We conclude that the presence of abdominal bloating/fullness but not any other upper gastrointestinal symptom is associated with diabetic gastroparesis and that gastric emptying is slower in diabetic women than in diabetic men.