The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology
The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology
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DOI：
10.1111/j.1365-3016.2006.00701.x
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发表时间：
2006-03-01
影响因子：
2.8
通讯作者：
Hattersley, AT
中科院分区：
文献类型：
--
作者：
Knight, B;Shields, BM;Hattersley, AT
埃克塞特儿童健康家庭研究是一项前瞻性研究，旨在检验胎儿胰岛素假说，并确定在决定出生体重和出生后早期生长发育方面发挥作用的基因多态。我们从埃克塞特中心一个邮政编码定义的地区招募了1017个家庭。建立了特定的纳入标准，以获得一个同质的、非糖尿病的英国高加索人队列。父母双方在怀孕28周时，以及他们的孩子出生时、12周、1岁和2岁时进行了详细的人体测量。在空腹的父母样本中检测胰岛素和其他生化分析，并在分娩时采集脐带血样本，提取父母和子女的DNA，以便对与胎儿生长有关的候选基因进行分子遗传分析。这一全面的数据集是在一个无疾病的队列中提供的，详细的准备工作确保了高水平的质量控制。这项研究将欢迎在严格的保密规则下进行合作。
The Exeter Family Study of Childhood Health is a prospective study, set up to test the fetal insulin hypothesis, and to identify genetic polymorphisms that play a role in determining birthweight and early postnatal growth. We recruited 1017 families from a postcode-defined area in central Exeter. Specific inclusion criteria were established to obtain a homogeneous, non-diabetic, UK Caucasian cohort. Detailed anthropometric measurements were taken from both parents at 28 weeks' gestation, and from their children at birth, 12 weeks, 1 year and 2 years of age. Insulin and other biochemical analysis were measured in fasting parental samples and an umbilical cord blood sample taken at delivery Parental and offspring DNA were extracted to allow molecular genetic analysis of candidate genes implicated in fetal growth. This comprehensive data set is available on a disease-free cohort, and detailed preparatory work has ensured high levels of quality control. The study would welcome collaboration within strict confidentiality rules.