Comparison between thromboelastography and conventional coagulation assays in patients with deep vein thrombosis
Comparison between thromboelastography and conventional coagulation assays in patients with deep vein thrombosis
复制标题
深静脉血栓患者血栓弹力图与常规凝血检测的比较
DOI：
10.1016/j.cca.2021.06.019
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发表时间：
2021-06-18
影响因子：
5
通讯作者：
Fan, Cheng
中科院分区：
文献类型：
--
作者：
Mao, Chaoqin;Xiong, Yueshan;Fan, Cheng
背景：传统的凝血检测（CCA）在评估深静脉血栓（DVT）患者的凝血状态方面价值有限。我们的目的是比较血栓弹力图 (TEG) 和 CCA 在识别 DVT 和评估 DVT 患者凝血状态方面的作用。方法：纳入了 66 名诊断为 DVT 的患者和 40 名健康对照者。在患者入院后 4 小时内进行任何手术前采集血样，并通过 TEG 和 CCA 进行检测。比较 DVT 患者和对照组之间的 TEG 和 CCA 参数。评估了每个参数识别 DVT 的能力。 Pearson相关性用于确定研究人群中TEG和CCA参数之间的相关性。结果：TEG在DVT患者和对照之间显示出显着差异，表明患有DVT的患者存在高凝倾向。相比之下，DVT 组和对照组之间的 CCA 没有显着差异。此外，TEG 在识别 DVT 方面表现出比 CCA 更好的能力。此外，Pearson的相关性分析显示TEG和CCA参数几乎没有相关性。结论：TEG在识别DVT和检测高凝状态方面具有优势，并且比CCA能够更好地评估DVT患者的凝血状态。
Background: Conventional coagulation assays (CCAs) are of limited value in the assessment of coagulation status in patients with deep vein thrombosis (DVT). We aimed to compare thromboelastography (TEG) and CCAs in identifying DVT and evaluating coagulation status in DVT patients.Methods: Sixty-six patients diagnosed with DVT and forty healthy controls were enrolled. Blood samples were collected within 4 h of patients' admission to hospital before any operation and tested by TEG and CCAs. TEG and CCA parameters were compared between DVT patients and controls. The ability of each parameter in identifying DVT was assessed. Pearson's correlation was used to determine the correlation between TEG and CCA parameters among the study population.Results: TEG showed significant differences between DVT patients and controls, indicating a hypercoagulable tendency in patients suffering from DVT. In contrast, no significant difference regarding CCAs was observed between the DVT and control group. Furthermore, TEG displayed a better capacity in identifying DVT than CCAs. In addition, Pearson's correlation analysis showed TEG and CCA parameters had few correlations.Conclusion: TEG has advantages in identifying DVT and detecting hypercoagulability, and provides a better insight in evaluating coagulation status in patients with DVT than CCAs.