Cutting edge:: Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells
Cutting edge:: Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells
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DOI：
10.4049/jimmunol.172.8.4676
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发表时间：
2004-04-15
影响因子：
4.4
通讯作者：
Kaveri, SV
中科院分区：
文献类型：
--
作者：
Misra, N;Bayry, J;Kaveri, SV
在小鼠和人类系统中，CD4(+)CD25(+)调节细胞的特征和功能已经被很好地定义。然而，CD4(+)CD25(+)T细胞与树突状细胞(DC)之间的相互作用尚不清楚。在这项研究中，我们检测了人CD4(+)CD25(+)T细胞对单核细胞来源的DC成熟和功能的影响。我们表明，尽管CD40配体预刺激，调节性T细胞使DC作为APC的效率低下。这一效应可通过中和抗体转化为转化生长因子-β而略微逆转。树突状细胞IL-10分泌增加，共刺激分子表达减少，因此，调节性T细胞除了对CD4(+)T细胞有直接抑制作用外，还可能通过DC调节免疫应答。
The characteristics and functions of CD4(+) CD25(+) regulatory cells have been well defined in murine and human systems. However, the interaction between CD4(+) CD25(+) T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4(+) CD25(+) T cells on maturation and function of monocyte-derived DC We show that regulatory T cell render the DC inefficient as APCs despite prestimulation with CD40 ligand. This effect was marginally reverted by neutralizing Abs to TGF-beta. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC Thus, in addition to direct suppressor effect on CD4(+) T cell, regulatory T cells may modulate the immune response through DC.