Dynamics and control of the global tuberculosis epidemic.
Dynamics and control of the global tuberculosis epidemic.
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DOI：
10.1097/00063198-200005000-00002
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发表时间：
2000-05-01
影响因子：
3.3
通讯作者：
Raviglione, M C
中科院分区：
文献类型：
--
作者：
Bleed, D;Dye, C;Raviglione, M C
对疾病负担的研究再次证实，结核病是世界十大死因之一。通过实施世界卫生组织（卫生组织）的短期直接观察治疗战略，大多数国家的结核病疫情最终可以得到控制，尽管非洲与人体免疫缺陷病毒（艾滋病毒）有关的结核病和前苏联的耐多药结核病迫切需要调整和扩大短期直接观察治疗。大多数高发国家的治疗成功率已接近世卫组织试点项目中85%的目标。从长远来看，我们可能会有更好的诊断方法、药物和疫苗来控制疾病;未来5年，全球结核病控制的中心问题是扩大DOTS在高发病率国家的覆盖范围。改善病例发现和诊断，加上最佳实践的短程化疗，可以迅速大幅减少因结核病而失去的健康生命年数，特别是通过预防死亡。
Studies of disease burden have reaffirmed that tuberculosis is among the top 10 causes of death in the world. The tuberculosis epidemic in most countries could eventually be brought under control by implementing the World Health Organization's (WHO) directly observed therapy, short course (DOTS) strategy, although tuberculosis linked to human immunodeficiency virus (HIV) in Africa and multidrug-resistant tuberculosis (MDR-TB) in the former Soviet Union urgently demand adaptations and extensions of DOTS. Most high-incidence countries have achieved treatment success rates approaching the WHO 85% target in pilot projects. In the long term, we may have better diagnostics, drugs, and vaccines to control the disease; for the next 5 years, the central problem in global tuberculosis control is to expand DOTS coverage in high-incidence countries. Improved case finding and diagnosis, coupled with best-practice short-course chemotherapy, could quickly and dramatically cut the number of years of healthy life lost due to tuberculosis, especially by preventing death.