Progress report of the single particle irradiation system to cell (SPICE)
Progress report of the single particle irradiation system to cell (SPICE)
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DOI：
10.1016/j.nimb.2007.01.253
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发表时间：
2007-07-01
影响因子：
1.3
通讯作者：
Yukawa, Masae
中科院分区：
文献类型：
--
作者：
Imaseki, Hitoshi;Ishikawa, Takahiro;Yukawa, Masae
2003年，我们在国立放射科学研究所（NIRS）建立了一个微束系统，单粒子照射细胞，SPICE。从2005年开始，我们重新设计了它，以提高系统的光学对准的稳定性，并获得了与物体狭缝的垂直尺寸成比例的光束尺寸的减小。因此，SPICE现在能够产生直径约为10 μ m的光束尺寸，并且粒子数量可控制到低至每秒单个粒子的强度，因此已经成功地实现了单粒子辐照设施。此外，这些条件可以通过采用常规程序容易地再现。我们详细描述了光束线的修改和结果，证明了改进。此外，还展示了我们第一次生物实验的结果。(c)2007 Elsevier B.V.保留所有权利。
At the National Institute of Radiological Sciences (NIRS), we constructed a microbeam system in 2003, the single particle irradiation to cell, SPICE. From the beginning of 2005, we redesigned it to improve the stability of the optical alignment of the system, and obtained an reduction of the beam size proportional to the vertical dimension of the object slits. As a result, SPICE is now capable of producing a beam size of approximately 10 pm diameter, and the particle numbers controllable to an intensity as low as single particles per second, and therefore a single particle irradiation facility has been successfully implemented. Moreover, these conditions can be easily reproduced with a employing a routine procedure. We describe in detail the modifications of the beam line and results, demonstrating the improvements. In addition, results from our first biological experiments are shown. (c) 2007 Elsevier B.V. All rights reserved.