Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery.
Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery.
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DOI：
10.1146/annurev-bioeng-082615-030519
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发表时间：
2016-07
影响因子：
9.7
通讯作者：
B. Narasimhan;Jonathan T. Goodman;J. E. Vela Ramirez
中科院分区：
文献类型：
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作者：
B. Narasimhan;Jonathan T. Goodman;J. E. Vela Ramirez
先天免疫细胞上的模式识别受体在指导细胞如何与生物体的其余部分相互作用以及确定下游免疫应答的方向方面发挥重要作用。最近的进展已经阐明了这些受体的结构和功能，为开发治疗感染，癌症和神经系统疾病的靶向药物和疫苗提供了新的机会。C型凝集素受体、Toll样受体和叶酸受体因其内吞其配体或启动影响免疫应答的信号传导途径的能力而引起人们的兴趣。目前正在开发几种新技术来吸引这些受体，包括重组抗体、过继免疫疗法、化学修饰抗原和药物递送载体。这些主动靶向技术将有助于解决目前药物和疫苗输送面临的挑战，并导致治疗人类疾病的新工具。
Pattern recognition receptors on innate immune cells play an important role in guiding how cells interact with the rest of the organism and in determining the direction of the downstream immune response. Recent advances have elucidated the structure and function of these receptors, providing new opportunities for developing targeted drugs and vaccines to treat infections, cancers, and neurological disorders. C-type lectin receptors, Toll-like receptors, and folate receptors have attracted interest for their ability to endocytose their ligands or initiate signaling pathways that influence the immune response. Several novel technologies are being developed to engage these receptors, including recombinant antibodies, adoptive immunotherapy, and chemically modified antigens and drug delivery vehicles. These active targeting technologies will help address current challenges facing drug and vaccine delivery and lead to new tools to treat human diseases.