BIOSYNTHESIS OF DITERPENE ANTIBIOTIC, APHIDICOLIN, BY RADIOISOTOPE AND C-13 NUCLEAR MAGNETIC-RESONANCE METHODS
BIOSYNTHESIS OF DITERPENE ANTIBIOTIC, APHIDICOLIN, BY RADIOISOTOPE AND C-13 NUCLEAR MAGNETIC-RESONANCE METHODS
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DOI：
10.1039/c39750000389
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发表时间：
1975-01-01
影响因子：
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通讯作者：
BULOCK, JD
中科院分区：
文献类型：
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作者：
ADAMS, MR;BULOCK, JD
用1，2 - 13 C2-乙酸酯和2- 14 C-4 R-3 H-甲羟戊酸酯前体的光谱和降解方法表明，阿非迪霉素是由二萜链的初始椅船环化，随后是连续的H-移位、环化和重排步骤产生的。
Spectroscopic and degradative methods with 1,2-13C2-acetate and 2-14C-4R-3H-mevalonate precursors show that aphidicolin arises from initial chair-boat cyclization of the diterpene chain followed by successive H-shift, cyclization, and rearrangement steps.