Synthesis of lipophilic 2-oxoamides based on γ-aminobutyric and δ-aminovaleric analogues and their activity against phospholipase A2
Synthesis of lipophilic 2-oxoamides based on γ-aminobutyric and δ-aminovaleric analogues and their activity against phospholipase A2
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DOI：
10.1002/psc.889
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发表时间：
2007-10-01
影响因子：
2.1
通讯作者：
Kokotos, George
中科院分区：
文献类型：
--
作者：
Moutevelis-Minakakis, Panagiota;Neokosmidi, Afroditi;Kokotos, George
合成了多种基于γ-氨基丁酸和δ-氨基戊酸类似物的亲脂性2-氧代酰胺。含有四唑、硫乙基或硫乙酰基的2-氧酰胺是GIVA cPLA(2)的弱抑制剂，而含有甲基四唑、膦酸二乙酯或硫乙基的衍生物是GV sPLA(2)的弱抑制剂。版权所有 (C) 2007 欧洲肽协会和 John Wiley & Sons, Ltd.
A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2). Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.