Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men.
Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men.
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发表时间：
2001-05
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通讯作者：
A. Wu;A. Whittemore;L. Kolonel;F. Stanczyk;E. John;R. Gallagher;D. West
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作者：
A. Wu;A. Whittemore;L. Kolonel;F. Stanczyk;E. John;R. Gallagher;D. West
内源性5 α还原酶活性较高的男性患前列腺癌的风险较高。这一假设提出了两个问题：(a) 5 α还原酶活性的种族差异能否解释前列腺癌风险的种族差异？(b)一个人可以通过改变他的生活方式来减少他的活动量吗？为了解决这些问题，我们分别在前列腺癌高、中、低风险的健康、年长的非裔美国人、白人和亚裔美国人中测量了两种激素指标- 5 -还原酶活性[血清中雄甾-3 - α -17 - β -二醇葡萄糖醛酸酯（3 - α -二醇G）和雄酮葡萄糖醛酸酯（AG）水平]。我们还研究了这些代谢物水平与生活方式特征之间的关系，如体型和体育活动，以及前列腺癌病史和家族史的某些方面。本横断面分析中纳入的男性（n = 1054）是我们在加利福尼亚、夏威夷和加拿大温哥华进行的一项基于人群的前列腺癌病例对照研究的对照对象，他们提供了1990年3月至1992年3月期间的某些个人特征和献血信息。在本研究中，3 α -二醇G浓度随年龄的增长而显著下降，随体重指数的增加而显著升高。3 α -二醇G的平均水平，经年龄和体重指数调整后，非洲裔美国人为6.1纳克/毫升，白人为6.9纳克/毫升，亚裔为4.8纳克/毫升。这些差异具有统计学意义（非裔美国人与白人：P < 0.01；白人与亚裔美国人：P < 0.001）。AG的浓度随着年龄的增长而显著下降，但仅在白人中，并且与任何报告的个人属性无关。经年龄调整后，非洲裔美国人的平均AG水平为44.1 ng/ml，白人为44.9 ng/ml，亚裔美国人为37.5 ng/ml（亚裔美国人与白人相比，P < 0.001）。综上所述，老年非裔美国人和白人男性的5 - α还原酶活性这两项指标水平相似，且高于老年亚裔美国男性。这种差异可能与亚裔美国人患前列腺癌的风险较低有关。
Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? and (b) Could a man reduce his activity level by modifying his lifestyle? To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. We also examined associations between these metabolite levels and such lifestyle characteristics as body size and physical activity as well as select aspects of medical history and family history of prostate cancer. Men included in this cross-sectional analysis (n = 1054) had served as control subjects in a population-based case-control study of prostate cancer we conducted in California, Hawaii, and Vancouver, Canada and provided information on certain personal attributes and donated blood between March 1990 and March 1992. In this study, concentrations of 3alpha-diol G declined significantly with age and increased significantly with body mass index. Mean levels of 3alpha-diol G, adjusted for age and body mass index, were 6.1 ng/ml in African-Americans, 6.9 ng/ml in whites and 4.8 ng/ml in Asian-Americans. These differences were statistically significant (African-Americans versus whites: P < 0.01; whites versus Asian-Americans: P < 0.001). Concentrations of AG decreased significantly with age, but only in whites, and were unrelated to any of the reported personal attributes. Mean levels of AG, adjusted for age, were 44.1 ng/ml in African-Americans, 44.9 ng/ml in whites, and 37.5 ng/ml in Asian-Americans (Asian-Americans versus whites, P < 0.001). In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. This difference may be related to the lower prostate cancer risk in Asian-Americans.