Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini
Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini
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DOI：
10.1038/nsmb1218
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发表时间：
2007-04-01
影响因子：
16.8
通讯作者：
Mourelatos, Zissimos
中科院分区：
文献类型：
--
作者：
Kirino, Yohei;Mourelatos, Zissimos
Piwi相互作用RNAs(PiRNAs)是一类在雄性生殖细胞中特异且大量表达的小RNA。在这里，我们报告了piRNAs的3‘末端是2’-O-甲基化的；这种修饰可能对piRNAs的生物发生和功能有重要的意义。
Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.