Cytotoxic Polyphenols from the Fungus Penicillium expansum 091006 Endogenous with the Mangrove Plant Excoecaria agallocha
Cytotoxic Polyphenols from the Fungus Penicillium expansum 091006 Endogenous with the Mangrove Plant Excoecaria agallocha
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DOI：
10.1055/s-0032-1315395
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发表时间：
2012-11-01
期刊：
影响因子：
2.7
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Wang, Junfeng;Lu, Zhenyu;Zhu, Weiming
作为我们正在进行的海洋来源真菌的生物活性代谢物的化学研究的一部分，四种新的含有酚性没药烷和二苯醚单元的多酚，expansol C-F（1-4），和一种新的二苯醚衍生物，3-O-甲基二地衣酚（5），以及十二种已知化合物（6-17），从大戟科（Euphorbiaceae）红树林植物海桐（Excoecaria agallocha）内生的扩展青霉（Penicillium expansum）091006中分离得到。根据NMR和质谱法确定了新代谢产物的结构。其中，膨胀溶胶C（1）和E（3）对HL-60细胞株的IC_（50）值分别为18.2和20.8 μ M。结果表明，侧链上带有Delta（7）双键的二苯醚取代的酚类没药烷对HL-60细胞的细胞毒性略低于7-OH或7-OCH_3衍生物。
As part of our ongoing chemical investigation of biologically active metabolites from marine-derived fungi, four new polyphenols containing both phenolic bisabolane and diphenyl ether units, expansols C-F (1-4), and one new diphenyl ether derivative, 3-O-methyldiorcinol (5), as well as twelve known compounds (6-17), were isolated from Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha (Euphorbiaceae). The structures of the new metabolites were determined on the basis of NMR and mass spectroscopy. Among them, expansols C (1) and E (3) exhibited weak cytotoxicity against the HL-60 cell lines with IC50 values of 18.2 and 20.8 mu M, respectively. The results showed that diphenyl ether substituted phenolic bisabolanes with a Delta(7) double bond in the side chain are slightly less cytotoxic to HL-60 cell lines than the 7-OH or 7-OCH3 derivatives.