Protein translocation into the ERGIC: an upstream event of secretory autophagy
Protein translocation into the ERGIC: an upstream event of secretory autophagy
复制标题
蛋白质易位至 ERGIC：分泌性自噬的上游事件
DOI：
10.1080/15548627.2020.1768668
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发表时间：
2020-06
期刊：
影响因子：
13.3
通讯作者：
Liang Ge
中科院分区：
文献类型：
--
作者：
Lei Liu;Min Zhang;Liang Ge
巨噬/自噬最近被证明通过一种称为分泌性自噬的过程调节非常规蛋白质的分泌。分泌货物如何选择性地进入分泌自噬体一直是一个核心问题。我们最近的研究表明，货物转运到er -高尔基体中间室，一个为自噬体形成提供膜的室，是分泌货物进入囊泡的机制，可能是分泌性自噬的早期步骤。
ABSTRACT Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.