Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion
Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion
复制标题
DOI：
10.1067/mob.2000.105738
复制
发表时间：
2000-08-01
影响因子：
9.8
通讯作者：
Spitz, B
中科院分区：
文献类型：
--
作者：
Donders, GGG;Van Bulck, B;Spitz, B
目的：本研究旨在调查妊娠早期诊断为细菌性阴道病与妊娠 20 周以内终止妊娠之间可能存在的联系。 研究设计：对比利时佛兰德斯地区妊娠早期（妊娠 14 周）期间接受常规产前护理并拥有活单胎胎儿的妇女 (n = 228) 进行阴道微生物菌群检查。细菌性阴道病可以通过临床（Amsel 等人的标准）、显微镜（线索细胞）或细菌性阴道病相关细菌的培养来评估。对数据进行单变量（相对风险）和多变量分析。 结果：第一次产前检查时细菌性阴道病的存在与随后的早期妊娠流产密切相关（相对风险，5.4；95% 置信区间，2.5-11）。经过多变量分析，细菌性阴道病、人型支原体和解脲支原体与流产风险增加无关，但其他微生物与流产风险增加无关。结论：细菌性阴道病和支原体可能在自然流产和早期妊娠流产中发挥致病作用。
OBJECTIVE: This study was undertaken to investigate a possible link between first-trimester diagnosis of bacterial vaginosis and cessation of pregnancy at less than or equal to 20 weeks' gestation.STUDY DESIGN: Women (n = 228) who received routine prenatal care in Flanders, Belgium, during the first trimester (14 weeks' gestation) and had a living singleton fetus were examined for microbiologic flora of the vagina. Bacterial vaginosis was assessed either clinically (Amsel et at criteria), microscopically (clue cells), or by culture of bacterial vaginosis-associated bacteria. Data were analyzed univariately (relative risk) and multivariately.RESULTS: The presence of bacterial vaginosis at the first prenatal visit was strongly associated with subsequent early pregnancy loss (relative risk, 5.4; 95% confidence interval, 2.5-11). After multivariate analysis bacterial vaginosis, Mycoplasma hominis, and Ureaplasma urealyticum but not other microorganisms remained associated with an increased risk of miscarriage.CONCLUSION: Bacterial vaginosis and mycoplasmas may play causative roles in spontaneous abortion and early pregnancy loss.