Arthritis: its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008
Arthritis: its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008
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DOI：
10.1016/j.annepidem.2012.11.008
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发表时间：
2013-02-01
影响因子：
5.6
通讯作者：
Rye, Kerry-Anne
中科院分区：
文献类型：
--
作者：
Ong, Kwok Leung;Wu, Ben J.;Rye, Kerry-Anne
目的：关节炎与心血管疾病（cvd）相关。然而，在一项全国性的调查研究中，对关节炎的流行病学研究有限。因此，我们调查了自我报告的关节炎患病率及其与心血管疾病的关系。方法：对1999年至2008年美国国家健康与营养调查中15888名40岁及以上受试者的数据进行分析。CVD定义为自我报告的心脏病发作、充血性心力衰竭、冠心病、心绞痛或中风史。结果：40岁及以上受试者自我报告的关节炎总体患病率从1999年至2000年的33.5%上升到2007年至2008年的37.0%（趋势P = 0.017）。在1999年至2008年患有关节炎的受试者中，35.3%患有骨关节炎（OA）， 17.9%患有类风湿性关节炎（RA）， 10.2%患有其他类型的关节炎，但36.6%不知道自己的关节炎类型。与无OA的受试者相比，OA患者患心血管疾病的几率更高（比值比[OR]， 1.53; P < .001），尤其是心绞痛（OR, 2.18: P < .001）。与没有类风湿关节炎的受试者相比，类风湿关节炎患者发生心血管疾病的几率更高（校正OR, 239; P < .001），尤其是充血性心力衰竭（OR, 3.59; P < .001）。结论：在一般人群中，RA和OA都与心血管疾病密切相关。它们之间的因果关系有待进一步研究。(c) 2013爱思唯尔公司版权所有。
Objective: Arthritis is associated with cardiovascular diseases (CVDs). However, there are limited epidemiologic studies on arthritis in a national survey study. We therefore investigated-the prevalence of self-reported arthritis and its association with CVDs.Methods: Data from 15,888 subjects aged 40 years or older in the United States National Health and Nutrition Examination Survey 1999 through 2008 were analyzed. CVD was defined as a self-reported history of heart attack, congestive heart failure, coronary heart disease, angina, or stroke.Results: The overall prevalence of self-reported arthritis in subjects aged 40 years or older increased from 33.5% in 1999 through 2000 to 37.0% in 2007 through 2008 (P for trend = 0.017). Among subjects with arthritis in 1999 through 2008, 35.3% had osteoarthritis (OA), 17.9% had rheumatoid arthritis (RA), and 10.2% had other types of arthritis, but 36.6% were unaware of their type of arthritis. Compared with subjects without OA, subjects with OA had higher odds for CVDs (odds ratio [OR], 1.53; P < .001), especially angina (OR, 2.18: P < .001). Compared with subjects without RA, subjects with RA had higher odds for CVDs (adjusted OR, 239; P < .001), especially congestive heart failure (OR, 3.59; P < .001).Conclusions: Both RA and OA are strongly associated with CVDs in the general population. Further studies are needed to investigate their causal relationship. (c) 2013 Elsevier Inc. All rights reserved.