Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.
Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.
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巨自噬和分子伴侣介导的自噬之间的串扰：对神经系统疾病治疗的影响
DOI：
10.1007/s12035-014-8933-0
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发表时间：
2015-12
影响因子：
5.1
通讯作者：
Hong Y
中科院分区：
文献类型：
--
作者：
Wu H;Chen S;Ammar AB;Xu J;Wu Q;Pan K;Zhang J;Hong Y
大自噬和分子伴侣介导的自噬（CMA）是自噬的两个重要亚型，在生理和病理条件下在细胞质量控制中起关键作用。尽管这两种自噬途径之间存在显著差异，但在自噬-溶酶体降解过程中，特别是在神经系统疾病的背景下，大自噬和CMA彼此密切相关。大自噬作为去除故障蛋白质的备用机制（即，当CMA受损时，细胞质中的异常α-突触核蛋白），反之亦然。巨自噬和CMA之间的对话的分子机制正在澄清。在此，我们调查目前的综述集中在macroautophagy和CMA之间的复杂的相互作用，并通过利用和操纵macroautophagy-CMA串扰在治疗神经系统疾病的治疗潜力。
Macroautophagy and chaperone-mediated autophagy (CMA) are two important subtypes of autophagy that play a critical role in cellular quality control under physiological and pathological conditions. Despite the marked differences between these two autophagic pathways, macroautophagy and CMA are intimately connected with each other during the autophagy-lysosomal degradation process, in particular, in the setting of neurological illness. Macroautophagy serves as a backup mechanism to removal of malfunctioning proteins (i.e., aberrant α-synuclein) from the cytoplasm when CMA is compromised, and vice versa. The molecular mechanisms underlying the conversation between macroautophagy and CMA are being clarified. Herein, we survey current overviews concentrating on the complex interactions between macroautophagy and CMA, and present therapeutic potentials through utilization and manipulation of macroautophagy-CMA crosstalk in the treatment of neurological diseases.