An analysis of thoracic and abdominal tumour motion for stereotactic body radiotherapy patients
An analysis of thoracic and abdominal tumour motion for stereotactic body radiotherapy patients
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DOI：
10.1088/0031-9155/53/13/016
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发表时间：
2008-07-07
影响因子：
3.5
通讯作者：
Keall, Paul J.
中科院分区：
文献类型：
--
作者：
Suh, Yelin;Dieterich, Sonja;Keall, Paul J.
对42例患者的143个治疗分数，使用外部和内部运动之间的相关性估计的超过70小时的肿瘤运动，对立体定向体部放疗患者的胸部和腹部肿瘤运动进行分析。肿瘤部位包括肺（30例患者）和腹膜后（12例患者）。总体平均诱导峰谷距离为0.48 cm，个体给药分数平均值范围为0.02 - 1.44 cm。总体平均呼吸周期为3.8 s，个体治疗分数平均值范围为2.2 - 6.4 s。在57个治疗部分（40%）中，平均诱导峰谷距离大于0.5 cm。一般而言，肿瘤运动主要是上下运动（占所有治疗部分的60%），而前后和左右运动分别为22%和18%。运动主要为线性，第一主成分的总体平均值为94%。然而，对于运动幅度、方向和线性，观察到患者之间、部分之间和周期之间的较大变化。
An analysis of thoracic and abdominal tumour motion for stereotactic body radiotherapy patients was performed using more than 70 h of tumour motion estimated from the correlation between the external and internal motion for 143 treatment fractions in 42 patients. The tumour sites included lungs (30 patients) and retroperitoneum (12 patients). The overall mean respiratory-induced peak-to-trough distance was 0.48 cm, with individual treatment fraction means ranging from 0.02 to 1.44 cm. The overall mean respiratory period was 3.8 s, with individual treatment fraction means ranging from 2.2 to 6.4 s. In 57 treatment fractions (40%), the mean respiratory-induced peak-to-trough distance was greater than 0.5 cm. In general, tumour motion was predominantly superior-inferior (60% of all the treatment fractions), while anterior-posterior and left-right motion were 22% and 18%, respectively. The motion was predominantly linear, and the overall mean of the first principal component was 94%. However, for motion magnitude, direction and linearity, large variations were observed from patient to patient, fraction to fraction and cycle to cycle.