EFFECT OF OXYGEN ON IMPAIRMENT OF PROLIFERATIVE CAPACITY OF HUMAN CELLS IN CULTURE BY IONIZING RADIATIONS OF DIFFERENT LET
EFFECT OF OXYGEN ON IMPAIRMENT OF PROLIFERATIVE CAPACITY OF HUMAN CELLS IN CULTURE BY IONIZING RADIATIONS OF DIFFERENT LET
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DOI：
10.1080/09553006614550421
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发表时间：
1966-01-01
期刊：
影响因子：
--
通讯作者：
PARNELL, CJ
中科院分区：
文献类型：
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作者：
BARENDSEN, GW;KOOT, CJ;PARNELL, CJ
氧增强比（OER）已被确定为抑制克隆形成的培养细胞的人类起源与[α]粒子和不同能量的氘，快中子和250 kvp的X射线照射。单能带电粒子的实验结果表明，随着线性能量转移（LET）从约2。6在LET[图片] 5。6 kev/[mu]的单位密度组织的值为2。05在61 kev/[mu]，随后更快速地下降到1。0，165 keV/[mu]。用16 MeV的氘轰击Be产生的快中子，OER为1。6，用250 kvp X射线，OER为2。7.讨论了相对生物学效应（RBE）、OER和LET之间的关系。
Oxygen-enhancement ratios (OER) have been determined for the inhibition of clone-formation by cultured cells of human origin irradiated with [alpha]-particles and deuterons of different energies, fast neutrons and 250 kvp x-rays. The results of experiments with mono-energetic charged particles, whereby narrow distributions of linear energy transfer (LET) are obtained, show that the OER decreases with increasing LET from about 2. 6 at a LET[image] of 5. 6 kev/[mu] of unit density tissue to a value of 2. 05 at 61 kev/[mu], followed by a more rapid decrease to 1. 0 at 165 kev/[mu] . With fast neutrons, produced by bombarding Be with 16 MeV deuterons, an OER of 1. 6 was obtained and with 250 kvp x-rays the OER was 2. 7. The relation between the relative biological effectiveness (RBE), the OER and the LET is discussed.