Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus
Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus
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DOI：
10.1111/j.1464-5491.2007.02267.x
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Rademacher, T. W.
中科院分区：
文献类型：
--
作者：
Scioscia, M.;Kunjara, S.;Rademacher, T. W.
目的正常妊娠期间胰岛素抵抗的机制及其在妊娠合并妊娠糖尿病（GDM）时的进一步恶化尚不清楚。肌醇磷酸聚糖p型（P-IPG）被认为是胰岛素的第二信使，与糖尿病患者胰岛素抵抗的程度有关。最近有报道称，在正常妊娠期间，母婴室的发病率有所增加。方法对48例GDM妇女和23例健康孕妇进行横断面研究。通过尿标本中丙酮酸脱氢酶磷酸酶的激活分光光度法测定尿中P-IPG水平，并与临床参数相关。结果GDM组P- ipg尿排泄量明显高于对照组（312.1 +/- 151.0比210.6 +/- 82.7 nmol NADH/min/mg肌酐，P < 0.01），且在妊娠期间升高（r(2) = 0.34, P < 0.01）。糖尿病组P- ipg与血糖水平(r（2) = 0.39，餐后血糖水平P < 0.01，平均血糖水平r(2) = 0.18, P < 0.01）和出生体重相关（r(2) = 0.14, P < 0.01）。结论GDM患者尿P-IPG排泄量增加，且与血糖水平呈正相关。P-IPG可能在GDM的母体血糖控制中发挥作用，并可能在胎儿生长中发挥作用。
Objective The mechanisms underlying insulin resistance during normal pregnancy, and its further exacerbation in pregnancies complicated by gestational diabetes mellitus (GDM), are generally unknown. Inositolphosphoglycan P-type (P-IPG), a putative second messenger of insulin, correlates with the degree of insulin resistance in diabetic subjects. An increase during normal pregnancy, in maternal and fetal compartments, has recently been reported.Methods A cross-sectional study was carried out in 48 women with GDM and 23 healthy pregnant women. Urinary levels of P-IPG were assessed spectrophotometrically by the activation of pyruvate dehydrogenase phosphatase in urinary specimens and correlated with clinical parameters.Results Urinary excretion of P-IPG was higher in GDM than in control women (312.1 +/- 151.0 vs. 210.6 +/- 82.7 nmol NADH/min/mg creatinine, P < 0.01) with values increasing throughout pregnancy in control subjects (r(2) = 0.34, P < 0.01). P-IPG correlated with blood glucose levels (r(2) = 0.39, P < 0.01 for postprandial glycaemia and r(2) = 0.18 P < 0.01 for mean glycaemia) and birthweight in the diabetic group (r(2) = 0.14, P < 0.01).Conclusions Increased P-IPG urinary excretion occurs in GDM and positively correlates with blood glucose levels. P-IPG may play a role in maternal glycaemic control and, possibly, fetal growth in GDM.