A new family of regulators of G-protein-coupled receptors?
A new family of regulators of G-protein-coupled receptors?
复制标题
DOI：
10.1016/s0960-9822(02)00454-2
复制
发表时间：
1996-02-01
期刊：
影响因子：
9.2
通讯作者：
Tyers, M
中科院分区：
文献类型：
--
作者：
Siderovski, DP;Hessel, A;Tyers, M
各种生物，如真菌和人类，使用G蛋白偶联受体来控制对各种激素、神经调节分子和其他感官刺激做出反应的信号转导通路[1]。对这些受体的持续刺激通常会导致它们的脱敏，这在一定程度上是由两个蛋白质家族的连续作用所介导的--G蛋白偶联受体激酶，它使激动剂占据的受体磷酸化[2]，以及arrestin蛋白，它随后与受体结合[3]。我们现在提出的证据表明，一组蛋白质--GOS8/Sst2p家族--可能是第三类受体脱敏因子。
Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins - the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins - the GOS8/Sst2p family - may be a third class of receptor-desensitizing factors.