Usefulness of critical flicker fusion frequency measurement and its laterality for evaluating compressive optic neuropathy due to pituitary neuroendocrine tumors
Usefulness of critical flicker fusion frequency measurement and its laterality for evaluating compressive optic neuropathy due to pituitary neuroendocrine tumors
复制标题
临界闪烁融合频率测量及其偏侧性在评估垂体神经内分泌肿瘤引起的压迫性视神经病变中的有用性
DOI：
10.1007/s10143-022-01915-z
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发表时间：
2022
影响因子：
2.8
通讯作者：
Horie Nobutaka
中科院分区：
文献类型：
--
作者：
Taguchi Akira;Kinoshita Yasuyuki;Tokumo Kana;Tominaga Atsushi;Kiuchi Yoshiaki;Yamasaki Fumiyuki;Horie Nobutaka
临界闪烁融合频率（CFF）是一种短而灵敏的视神经功能评价方法。我们测量了垂体神经内分泌肿瘤（Pit-NETs）患者的CFF，以评估其有用性。这项回顾性研究使用了184例无功能性Pit-NET患者的数据，这些患者接受了经蝶手术治疗，并且没有眼部疾病病史。视敏度下降（VAD）定义为logMAR视敏度下降> 0.10，CFF下降（CFD）定义为CFF值< 35 Hz。在Humphrey视野分析仪上通过自动视野检查评估视野缺损（VFD）。分析了异常检查结果与鞍上肿瘤高度之间的潜在相关性。视神经或视交叉与肿瘤接触分别为161例和23例。在显示接触的患者中，左眼和右眼之间的CFF差异较大（p= 0.0008），使用受试者工作特征曲线的最佳截止值为3 Hz。因此，≥ 3 Hz被认为是CFF偏侧性（CFL）的阳性，这是最常见的情况。CFL阳性患者的肿瘤高度低于VAD或VFD患者（p< 0.01）。与其他检查相比，小肿瘤检查异常的患病率最高。CFL的变化允许早期发现Pit-NET。我们的研究结果表明，CFF偏侧性可以看出在早期阶段的压迫性视神经病变，由于Pit NET。
Critical flicker fusion frequency (CFF) is a short but sensitive method for evaluating optic nerve function. We measured CFF in patients with pituitary neuroendocrine tumors (Pit-NETs) to assess its usefulness. Data from 184 patients with nonfunctioning Pit-NETs, who had been treated with transsphenoidal surgery and had no medical history of eye diseases, was used in this retrospective study. Visual acuity decline (VAD) was defined as > 0.10 reduction in logMAR visual acuity and CFF decline (CFD) was defined as CFF value < 35 Hz. Visual field defect (VFD) was evaluated by automated perimetry on a Humphrey visual field analyzer. Potential associations between abnormal test results and tumor height from the suprasellar were analyzed. Contact between the optic nerve or chiasma and the tumor was present and absent in 161 and 23 patients, respectively. In patients showing contact, the difference in CFF between the left and right eyes was larger (p= 0.0008), and the optimal cutoff value using the receiver operating characteristic curve was 3 Hz. Therefore, ≥ 3 Hz was considered positive for CFF laterality (CFL), the most prevalent condition. Tumor height was lower in patients with CFL positivity compared to those with VAD or VFD (p< 0.01). The prevalence of test abnormalities was the highest for small tumors compared to those of other tests. Changes in CFL permit early detection of Pit-NETs. Our results indicate that CFF laterality can be seen in the early stages of compressive optic neuropathy due to Pit-NET.