Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis.
Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis.
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DOI：
10.1155/2011/591427
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发表时间：
2011
影响因子：
--
通讯作者：
Kitajima M
中科院分区：
文献类型：
--
作者：
Hayashida T;Jinno H;Kitagawa Y;Kitajima M
上皮-间充质转化(EMT)是一个多步骤的过程，在这个过程中细胞获得分子变化，如细胞-细胞连接的丢失和细胞骨架的重组。越来越多的人认识到，这一过程可能通过促进浸润性和转移性肿瘤的生长来促进乳腺癌的进展。最近的观察表明，EMT和癌症干细胞特性之间可能存在串扰，导致肿瘤致瘤性和产生异质肿瘤细胞群的能力增强。在这里，我们回顾了EMT参与肿瘤干细胞理论的实验和临床证据，重点介绍了这一现象的共同特征。
Epithelial-mesenchymal transition (EMT) is a multistep process in which cells acquire molecular alterations such as loss of cell-cell junctions and restructuring of the cytoskeleton. There is an increasing understanding that this process may promote breast cancer progression through promotion of invasive and metastatic tumor growth. Recent observations imply that there may be a cross-talk between EMT and cancer stem cell properties, leading to enhanced tumorigenicity and the capacity to generate heterogeneous tumor cell populations. Here, we review the experimental and clinical evidence for the involvement of EMT in cancer stem cell theory, focusing on the common characteristics of this phenomenon.